The AYAZAZI study team celebrated yesterday as it officially launched and recruited the first participant. This study is developing a cohort of adolescents and young adults (AYA) in Soweto and Durban, South Africa to identify, understand and link socio-behavioural, clinical, and biomedical patterns of risk for HIV acquisition and vaccine trial preparedness using a mixed method approach. The study is being conducted in Soweto  and Durban.